Over the years, the pharmaceutical industry has witnessed several advancements in drug development. It has gradually shifted from a one-drug treats all model to a more personalized approach of treatment, which involves the use of personalized cell therapies for various disease indications. This shift has led to an evident change in the pharmaceutical packaging domain as well. The cell therapy packaging is relatively complex than that of small molecule therapeutics and other biologics. It requires specific conditions for fill / finish, storage and transportation in order to maintain sterility and viability of cells at cryogenic temperatures and stringent quality standards. Considering the packaging, storage and drug administration-related demands of the modern healthcare industry, experts believe that a modular approach to packaging methods would be beneficial, both in terms of time and cost.
Currently, over 25 players across the globe claims to provide cell therapy packaging services Presently, the cell therapy packaging market is characterized by the presence of large (more than 500 employees), mid-sized (51-500 employees), small companies (2-50 employees).
Further, several companies also offer all the four cell therapy logistics services (packaging, storage, logistics and distribution). Examples include (in alphabetical order, no specific criteria for selection) Almac, ICS, Thermo Fisher Scientific and Yourway. Majority of these companies are large players, offering services for secondary packaging of cell therapies at all temperatures (ambient, refrigerated, freezing and cryogenic).
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Among the companies providing packaging services for cell therapies, majority of the companies (55%) were established during 1981-2010, examples include (in alphabetical order, no specific criteria for selection) Biocair, Cellex and Yourway. In addition, three companies were established in the last decade (post 2010); these are (in alphabetical order) A4P, Biotech and Pharma Logistics, and PackGene Biotech.
Secondary packaging is used to protect the primary packaging and keep the label intact under critical environmental conditions. This type of packaging uses cartons and metal cassettes to cover cryopreserved vials and bags containing cell therapy products.
In addition, majority of the service providers are based in North America (65%), followed by Europe (28%). Further, two companies (namely PackGene Biotech and Sequel Logistics) are based in Asia Pacific. Examples of companies based in North America include (in alphabetical order) Brooks Life Sciences, CSafe Global, United Parcel Services and WuXi Advanced Therapies.
Type of Packaging and Packaging Material
As is evident from the figure below, eight firms offer services for only passive packaging and one company (Catalent Biologics) offer services for only active packaging. Example of companies (6) offering both, active and passive packaging, include (in alphabetical order) Biocair, Marken and MNX Global Logistics.
Further, seven firms employ only liquid nitrogen as the packaging material and two companies (Catalent Biologics and CSafe Global) use only dry ice. Example of companies (7) using both, liquid nitrogen and dry ice packaging material, include (in alphabetical order) Cellex, Marken, MNX Global Logistics, World Courier and Yourway.
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